Doctors are considerably too lenient with antidepressants that target serotonin, despite the fact that very few of them understand cannabis, particularly the endocannabinoid system (ECS). Serotonin and the ECS are inextricably linked. Indeed, serotonin deficiency depression can have a wide range of impacts on the mind and immune system by disabling the endocannabinoid system (ECS).

The ECS is made up of messenger molecules, receptors, and endogenous compounds found in the cannabis plant.

The “happy” chemicals in your brain communicate via grossly underutilised channels. The microbiome, for example, is made up of trillions of creatures that live on the inside of your body. It is a vital component of both serotonin and the ECS.

The endocannabinoid system, the CB1 receptor, serotonin, and gut bacteria all have a feedback loop.
Cannabinoid receptors, gut microbes, and serotonin receptors all contribute to the maintenance of a feedback loop (5-HT receptors.) External influences can have a good or negative impact on this feedback loop, which can have a significant impact on mental health. (Green arrows denote an agonist-like function, red arrows an inhibitor-like function, and blue arrows with dotted lines a modulator-like function.)
Systemic serotonin deficiency
A serotonin deficiency can result in bouts of mental anguish, including serious depression. Nonetheless, we know that serotonin receptors connect directly to the endocannabinoid system, which is primarily poised to receive cannabis chemicals.

To begin, the endocannabinoid 2-AG, a biological workhorse, is partially regulated by the serotonin receptor 5-HT2a. Second, AA-5-HT (Arachidonoyl serotonin) is a highly effective endocannabinoid derived from serotonin. By activating CB1 receptors, AA-5-HT aids in the regulation of sleep and mood cycles. AA-5-HT, which is a cross between arachidonic acid and serotonin, also suppresses anandamide breakdown.

To question which came first, the faulty serotonin receptor or the low endocannabinoid tone, is much like asking which came first, the chicken or the egg. However, the solution may provide long-term relief. ECS health, for example, will be difficult to sustain if other processes, such as poor microbiota health and depression, also reduce serotonin levels.

The endocannabinoid system and depression

Through the 5HT2a receptor, serotonin promotes the endocannabinoid 2-AG. Low serotonin levels will result in a deficiency of 2-AG. Deficient CB2 receptors, on the other hand, may be the underlying root cause of a depressive episode via an interrelated loop of effects.
Depression and the endocannabinoid system
An endocannabinoid-positive lifestyle and food, rather than serotonin boosters, could be used to treat depression. Mental wellness will return once your complete body returns to balance, but we can’t make any promises. Serotonin and ECS deficiencies can be hereditary or caused by uncontrollable causes, necessitating the use of an exogenous treatment. Many clinicians focus on SRIs, or medications that increase serotonin levels, but this ignores the underlying connection between the ECS and the world we live in.

Endocannabinoid deficiency can have far-reaching health consequences that go beyond depression, such as pain and autoimmune issues. Depression induced by a low serotonin level can lead to a variety of physiological disorders that are inextricably linked to the endocannabinoid system.

Tell us in the comments how you deal with depression. Also, read this storey to learn how THC operates as the human half of an endocannabinoid, a relationship that connects into ADHD.…

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